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Structure paper

TitleDiscovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 1405-1409, Year 2010
Publish dateJul 13, 2009 (structure data deposition date)
AuthorsNishii, H. / Chiba, T. / Morikami, K. / Fukami, T.A. / Sakamoto, H. / Ko, K. / Koyano, H.
External linksBioorg. Med. Chem. Lett. / PubMed:20093027
MethodsX-ray diffraction
Resolution2.54 Å
Structure data

PDB-3a4p:
human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.54 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-DFQ:
(2E)-3-{6-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl}-N-methylprop-2-enamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / C-MET / TYROSINE-PROTEIN KINASE / HEPATOCYTE GROWTH FACTOR RECEPTOR

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