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Structure paper

TitleConformation switch of NPC1 epitomizes a lumen-to-membrane alternating access for nonpolar substrates
Journal, issue, pagesTo Be Published
Publish dateJul 25, 2026 (structure data deposition date)
AuthorsWu X / Dehghani-Ghahnaviyeh S / Rasouli A / Malona J / Antalek M / Jones LH / Fan X / Peng A / Tajkhorshid E / Qian H / Yan N
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.1 - 3.2 Å
Structure data

78289

37lu

EMDB-78289, PDB-37lu:
NPC1-NPC2 complex with bis-sterol molecule JM046, pH 5.5
Method: EM (single particle) / Resolution: 3.2 Å

78290

37lv

EMDB-78290, PDB-37lv:
NPC1 expressed from Sf9 and purified at pH 5.5
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CLR:
CHOLESTEROL

ChemComp-POV:
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate / phospholipid*YM

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / transporter / complex / viral entry

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