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TitleSystematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework
Journal, issue, pagesTo Be Published
Publish dateAug 9, 2026 (structure data deposition date)
AuthorsSchuster S / Hartl FA / Stehle J / Beier F / Al-Hasani H / Reinhart C / Weng T-H / Kraemer S / Hamde P / Herz T ...Schuster S / Hartl FA / Stehle J / Beier F / Al-Hasani H / Reinhart C / Weng T-H / Kraemer S / Hamde P / Herz T / Oesterlin S / Schmidt M / Gross T / Stehl L / Kilb N / Juenemann G / Heiss K / Sinclair A / Schoettgen J / Meyer P / Atay B / Zaghla BKQ / Link S / Goll J / Leoni B / Steinmann B / Selinger O / Welsch S / Roth G / Michel H / Klatt M / Birkenfeld J
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.2 - 2.4 Å
Structure data

59342

33cg

EMDB-59342, PDB-33cg:
Cryo-EM structure of MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-6
Method: EM (single particle) / Resolution: 2.2 Å

59343

33ch

EMDB-59343, PDB-33ch:
Cryo-EM structure of MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-4
Method: EM (single particle) / Resolution: 2.4 Å

59344

33ci

EMDB-59344, PDB-33ci:
Cryo-EM structure of MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-58
Method: EM (single particle) / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / HLA / MHC / antibody

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