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TitleSpyCEP dismantles neutrophil immunity via disorder-driven chemokine remodeling and GAG targeting
Journal, issue, pagesPNAS, Year 2026
Publish dateJun 12, 2026 (structure data deposition date)
AuthorsLau, R.J. / Giblin, S.P. / Sugar, A. / Di Maio, A. / Tassini, G. / Huse, K. / Chorev, D. / Chen, Y. / Wu, G.H.Y. / Huemer, C.B. ...Lau, R.J. / Giblin, S.P. / Sugar, A. / Di Maio, A. / Tassini, G. / Huse, K. / Chorev, D. / Chen, Y. / Wu, G.H.Y. / Huemer, C.B. / Kim, S.Y. / Matthews, J. / Muloud, B. / Chen, L. / McKenna, S. / Xu, Y. / Massai, L. / Muzzi, C. / Ferhati, X. / Necchi, F. / Moriel, D.G. / Feizi, T. / Liu, Y. / Pease, J.E. / Sriskandan, S. / Matthews, S.
External linksPNAS / Search PubMed
MethodsEM (single particle)
Resolution3.07 Å
Structure data

PDB-31mr:
CryoEM structure of a catalytically inactive CXC Chemokine-degrading protease SpyCEP from Streptococcus pyogenes complexed with an anti-PA-domain monoclonal antibody
Method: ELECTRON MICROSCOPY / Resolution: 3.07 Å

Source
  • streptococcus pyogenes (bacteria)
  • mus musculus (house mouse)
KeywordsPROTEIN BINDING / Bacterial / protease / complex / antibody / immune evasion / chemokine

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