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TitleAtomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands
Journal, issue, pagesFebs Lett., Vol. 583, Page 320-324, Year 2009
Publish dateNov 19, 2008 (structure data deposition date)
AuthorsWaku, T. / Shiraki, T. / Oyama, T. / Morikawa, K.
External linksFebs Lett. / PubMed:19101554
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2zvt:
Cys285Ser mutant PPARgamma ligand-binding domain complexed with 15-deoxy-delta12,14-prostaglandin J2
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-PTG:
(5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / ANTI PARALLEL HELIX SANDWICH / Activator / Alternative splicing / Diabetes mellitus / Disease mutation / DNA-binding / Metal-binding / Nucleus / Obesity / Phosphoprotein / Polymorphism / Receptor / Transcription regulation / Zinc / Zinc-finger

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