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Structure paper

TitleCrystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.
Journal, issue, pagesJ. Biol. Chem., Vol. 283, Page 21495-21500, Year 2008
Publish dateApr 16, 2008 (structure data deposition date)
AuthorsChu, M.L. / Chavas, L.M. / Douglas, K.T. / Eyers, P.A. / Tabernero, L.
External linksJ. Biol. Chem. / PubMed:18480048
MethodsX-ray diffraction
Resolution2.88 - 3.14 Å
Structure data

PDB-2zmc:
Crystal structure of human mitotic checkpoint kinase Mps1 catalytic domain apo form
Method: X-RAY DIFFRACTION / Resolution: 3.14 Å

PDB-2zmd:
Crystal structure of human Mps1 catalytic domain T686A mutant in complex with SP600125 inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.88 Å

Chemicals

ChemComp-7PE:
2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL

ChemComp-HOH:
WATER

ChemComp-537:
2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE / inhibitor*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase / Mps1 / mitosis / ATP-binding / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / Tyrosine-protein kinase / SP600125 / T686A

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