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Structure paper

TitleTranslational Regulation Via L11: Molecular Switches on the Ribosome Turned on and Off by Thiostrepton and Micrococcin.
Journal, issue, pagesMol. Cell, Vol. 30, Page 26-, Year 2008
Publish dateMar 7, 2008 (structure data deposition date)
AuthorsHarms, J.M. / Wilson, D.N. / Schluenzen, F. / Connell, S.R. / Stachelhaus, T. / Zaborowska, Z. / Spahn, C.M. / Fucini, P.
External linksMol. Cell / PubMed:18406324
MethodsX-ray diffraction
Resolution2.91 - 3.7 Å
Structure data

PDB-2zjp:
Thiopeptide antibiotic Nosiheptide bound to the large ribosomal subunit of Deinococcus radiodurans
Method: X-RAY DIFFRACTION / Resolution: 3.7 Å

PDB-2zjq:
Interaction of L7 with L11 induced by Microccocin binding to the Deinococcus radiodurans 50S subunit
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-2zjr:
Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans
Method: X-RAY DIFFRACTION / Resolution: 2.91 Å

PDB-3cf5:
Thiopeptide antibiotic Thiostrepton bound to the large ribosomal subunit of Deinococcus radiodurans
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NO1:
4-(hydroxymethyl)-3-methyl-1H-indole-2-carboxylic acid

ChemComp-MG:
Unknown entry

Source
  • deinococcus radiodurans (radioresistant)
  • streptomyces actuosus (bacteria)
  • streptomyces azureus (bacteria)
KeywordsRIBOSOME/ANTIBIOTIC / NOSIHEPTIDE / THIOPEPTIDE / THIAZOLE / ANTIBIOTIC / L11 / S50 / ANTIBACTERIAL / RIBOSOME-ANTIBIOTIC COMPLEX / RIBOSOME / ZINC-FINGER / TRANSLATION REGULATION / RNA-BINDING / ribosomal subunit / 50S / thiopeptide antibiotics / complex / translational regulation / molecular switch / L7 / Ribonucleoprotein / Ribosomal protein / rRNA-binding / tRNA-binding / Methylation / Metal-binding / large ribosomal subunit / THIOSTREPTON / RNA / THIAZOLINE / PYRIDINE / TRANSLATION INHIBITION

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