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TitleDiscovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)
Journal, issue, pagesBioorg. Med. Chem., Vol. 16, Page 4715-4732, Year 2008
Publish dateNov 27, 2007 (structure data deposition date)
AuthorsAsano, Y. / Kitamura, S. / Ohra, T. / Aso, K. / Igata, H. / Tamura, T. / Kawamoto, T. / Tanaka, T. / Sogabe, S. / Matsumoto, S. ...Asano, Y. / Kitamura, S. / Ohra, T. / Aso, K. / Igata, H. / Tamura, T. / Kawamoto, T. / Tanaka, T. / Sogabe, S. / Matsumoto, S. / Yamaguchi, M. / Kimura, H. / Itoh, F.
External linksBioorg. Med. Chem. / PubMed:18313304
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-2zdu:
Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-446:
4-[(4-{[6-bromo-3-(methoxycarbonyl)-1-oxo-4-phenylisoquinolin-2(1H)-yl]methyl}phenyl)amino]-4-oxobutanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PROTEIN KINASE / Alternative splicing / ATP-binding / Chromosomal rearrangement / Cytoplasm / Epilepsy / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase

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