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TitleSynthesis and Evaluation of Heteroarylalanine Diacids as Potent and Selective Neutral Endopeptidase Inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 3404-, Year 2011
Publish dateMar 2, 2011 (structure data deposition date)
AuthorsGlossop, M.S. / Bazin, R.J. / Dack, K.N. / Fox, D.N.A. / Macdonald, G.A. / Mills, M. / Owen, D.R. / Phillips, C. / Reeves, K.A. / Ringer, T.J. ...Glossop, M.S. / Bazin, R.J. / Dack, K.N. / Fox, D.N.A. / Macdonald, G.A. / Mills, M. / Owen, D.R. / Phillips, C. / Reeves, K.A. / Ringer, T.J. / Strang, R.S. / Watson, C.A.L.
External linksBioorg. Med. Chem. Lett. / PubMed:21515054
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-2yb9:
Crystal Structure of Human Neutral Endopeptidase complexed with a heteroarylalanine diacid.
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HA0:
HETEROARYLALANINE 5-PHENYL OXAZOLE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / NEPRILYSINE / METALLOPROTEINASE

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