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TitleNms-P937, a 4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline Derivative as Potent and Selective Polo-Like Kinase 1 Inhibitor.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 2969-, Year 2011
Publish dateFeb 18, 2011 (structure data deposition date)
AuthorsBeria, I. / Bossi, R.T. / Brasca, M.G. / Caruso, M. / Ceccarelli, W. / Fachin, G. / Fasolini, M. / Forte, B. / Fiorentini, F. / Pesenti, E. ...Beria, I. / Bossi, R.T. / Brasca, M.G. / Caruso, M. / Ceccarelli, W. / Fachin, G. / Fasolini, M. / Forte, B. / Fiorentini, F. / Pesenti, E. / Pezzetta, D. / Posteri, H. / Scolaro, A. / Depaolini, S.R. / Valsasina, B.
External linksBioorg. Med. Chem. Lett. / PubMed:21470862
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2yac:
Crystal structure of Polo-like kinase 1 in complex with NMS-P937
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-937:
1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE

ChemComp-ZN:
Unknown entry

ChemComp-TLA:
L(+)-TARTARIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ATP-BINDING / CELL CYCLE / CELL DIVISION / MITOSIS / NUCLEOTIDE-BINDING / NUCLEUS

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