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Structure paper

TitleStructure of Mammalian Ampk and its Regulation by Adp
Journal, issue, pagesNature, Vol. 472, Page 230-, Year 2011
Publish dateFeb 7, 2011 (structure data deposition date)
AuthorsXiao, B. / Sanders, M.J. / Underwood, E. / Heath, R. / Mayer, F. / Carmena, D. / Jing, C. / Walker, P.A. / Eccleston, J.F. / Haire, L.F. ...Xiao, B. / Sanders, M.J. / Underwood, E. / Heath, R. / Mayer, F. / Carmena, D. / Jing, C. / Walker, P.A. / Eccleston, J.F. / Haire, L.F. / Saiu, P. / Howell, S.A. / Aasland, R. / Martin, S.R. / Carling, D. / Gamblin, S.J.
External linksNature / PubMed:21399626
MethodsX-ray diffraction
Resolution2.5 - 3.24 Å
Structure data

PDB-2y8l:
Structure of the regulatory fragment of mammalian aMPK in complex with two ADP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2y8q:
Structure of the regulatory fragment of mammalian AMPK in complex with one ADP
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2ya3:
STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH COUMARIN ADP
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

PDB-4cfh:
Structure of an active form of mammalian AMPK
Method: X-RAY DIFFRACTION / Resolution: 3.24 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-HOH:
WATER

ChemComp-J7V:
3'-(7-diethylaminocoumarin-3-carbonylamino)-3'-deoxy-ADP

ChemComp-STU:
STAUROSPORINE / anticancer, antifungal, antibiotic, alkaloid*YM

Source
  • rattus norvegicus (Norway rat)
  • homo sapiens (human)
KeywordsTRANSFERASE / NUCLEOTIDE-BINDING / SERINE/THREONINE-PROTEIN KINASE / ADP / PHOSPHORYLATION / TRANSFERASE PHOSPHORYLATION / ACTIVE FORM / STAUROSPORINE-BINDING

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