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TitleThe Discovery of Potent and Long-Acting Oral Factor Xa Inhibitors with Tetrahydroisoquinoline and Benzazepine P4 Motifs.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 1588-, Year 2011
Publish dateFeb 2, 2011 (structure data deposition date)
AuthorsWatson, N.S. / Adams, C. / Belton, D. / Brown, D. / Burns-Kurtis, C.L. / Chaudry, L. / Chan, C. / Convery, M.A. / Davies, D.E. / Exall, A.M. ...Watson, N.S. / Adams, C. / Belton, D. / Brown, D. / Burns-Kurtis, C.L. / Chaudry, L. / Chan, C. / Convery, M.A. / Davies, D.E. / Exall, A.M. / Harling, J.D. / Irvine, S. / Irving, W.R. / Kleanthous, S. / Mclay, I.M. / Pateman, A.J. / Patikis, A.N. / Roethke, T.J. / Senger, S. / Stelman, G.J. / Toomey, J.R. / West, R.I. / Whittaker, C. / Zhou, P. / Young, R.J.
External linksBioorg. Med. Chem. Lett. / PubMed:21349711
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2y7x:
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MZA:
6-CHLORO-N-[(3S)-1-(5-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL)-2-OXO-PYRROLIDIN-3-YL]NAPHTHALENE-2-SULFONAMIDE

ChemComp-CA:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING / HYDROLASE / SERINE PROTEASE

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