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Structure paper

TitleA Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors.
Journal, issue, pagesPlos Biol., Vol. 9, Page 01034-, Year 2011
Publish dateNov 19, 2010 (structure data deposition date)
AuthorsBrams, M. / Pandya, A. / Kuzmin, D. / Van Elk, R. / Krijnen, L. / Yakel, J.L. / Tsetlin, V. / Smit, A.B. / Ulens, C.
External linksPlos Biol. / PubMed:21468359
MethodsX-ray diffraction
Resolution1.909 - 2.05 Å
Structure data

PDB-2xys:
Crystal structure of Aplysia californica AChBP in complex with strychnine
Method: X-RAY DIFFRACTION / Resolution: 1.909 Å

PDB-2xyt:
Crystal structure of Aplysia californica AChBP in complex with d- tubocurarine
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-SY9:
STRYCHNINE / alkaloid*YM

ChemComp-HOH:
WATER

ChemComp-TC9:
D-TUBOCURARINE / alkaloid*YM

Source
  • aplysia californica (California sea hare)
KeywordsRECEPTOR / AMIDATION / CONFORMATIONAL FLEXIBILITY / CONOTOXIN / NEUROTOXIN / NICOTINIC / POSTSYNAPTIC NEUROTOXIN / RECEPTOR-TOXIN COMPLEX / NEUROTOXIN NICOTINIC

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