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TitleA Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo.
Journal, issue, pagesJ. Lipid Res., Vol. 52, Page 78-, Year 2011
Publish dateOct 10, 2010 (structure data deposition date)
AuthorsNi, Y.G. / Di Marco, S. / Condra, J.H. / Peterson, L.B. / Wang, W. / Wang, F. / Pandit, S. / Hammond, H.A. / Rosa, R. / Cummings, R.T. ...Ni, Y.G. / Di Marco, S. / Condra, J.H. / Peterson, L.B. / Wang, W. / Wang, F. / Pandit, S. / Hammond, H.A. / Rosa, R. / Cummings, R.T. / Wood, D.D. / Liu, X. / Bottomley, M.J. / Shen, X. / Cubbon, R.M. / Wang, S.P. / Johns, D.G. / Volpari, C. / Hamuro, L. / Chin, J. / Huang, L. / Zhao, J.Z. / Vitelli, S. / Haytko, P. / Wisniewski, D. / Mitnaul, L.J. / Sparrow, C.P. / Hubbard, B. / Carfi, A. / Sitlani, A.
External linksJ. Lipid Res. / PubMed:20959675
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-2xtj:
The crystal structure of PCSK9 in complex with 1D05 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/ANTIBODY / HYDROLASE-ANTIBODY COMPLEX / SERINE PROTEASE / LDL-C / LDLR / EGF-A / HYPERCHOLESTEROLEMIA

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