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-Structure paper
Title | Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 5988-5993, Year 2010 |
Publish date | Aug 2, 2010 (structure data deposition date) |
![]() | Bouloc, N. / Large, J.M. / Kosmopoulou, M. / Sun, C. / Faisal, A. / Matteucci, M. / Reynisson, J. / Brown, N. / Atrash, B. / Blagg, J. ...Bouloc, N. / Large, J.M. / Kosmopoulou, M. / Sun, C. / Faisal, A. / Matteucci, M. / Reynisson, J. / Brown, N. / Atrash, B. / Blagg, J. / McDonald, E. / Linardopoulos, S. / Bayliss, R. / Bavetsias, V. |
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Methods | X-ray diffraction |
Resolution | 2.605 - 2.8 Å |
Structure data | ![]() PDB-2xne: ![]() PDB-2xng: |
Chemicals | ![]() ChemComp-ASH: ![]() ChemComp-HOH: ![]() ChemComp-A0H: |
Source |
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![]() | TRANSFERASE / SER-THR PROTEIN KINASE COMPLEX / PROTO-ONCOGENE / KINASE / MITOSIS / CELL CYCLE / MICROTUBULE / CYTOSKELETON / CELL DIVISION |