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Structure paper

TitleBinding Diversity of Pioglitazone by Peroxisome Proliferator-Activated Receptor-Gamma
Journal, issue, pagesTo be Published
Publish dateJul 14, 2010 (structure data deposition date)
AuthorsMueller, J.J. / Schupp, M. / Unger, T. / Kintscher, U. / Heinemann, U.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.02 Å
Structure data

PDB-2xkw:
LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST PIOGLITAZONE
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

Chemicals

ChemComp-P1B:
(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione / medication*YM

ChemComp-PE4:
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL / precipitant*YM

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / NUCLEAR RECEPTOR / TRANSCRIPTION FACTOR / GENE REGULATION / THIAZOLIDINEDIONE

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