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Structure paper

TitleDiscovery of the Selective Vegfr Inhibitor Pf- 00337210
Journal, issue, pagesTo be Published
Publish dateJun 30, 2010 (structure data deposition date)
AuthorsMctigue, M. / Wickersham, J. / Marrone, T.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-2xir:
Crystal structure of the VEGFR2 kinase domain in complex with PF- 00337210 (N,2-dimethyl-6-(7-(2-morpholinoethoxy)quinolin-4-yloxy) benzofuran-3-carboxamide)
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-00J:
N,2-DIMETHYL-6-{[7-(2-MORPHOLIN-4-YLETHOXY)QUINOLIN-4-YL]OXY}-1-BENZOFURAN-3-CARBOXAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ANGIOGENESIS / NUCLEOTIDE-BINDING / INHIBITOR / PHOSPHORYLATION / RECEPTOR / TRANSMEMBRANE

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