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| Title | Small-Molecule P21-Activated Kinase Inhibitor Pf- 3758309 is a Potent Inhibitor of Oncogenic Signaling and Tumor Growth. |
|---|---|
| Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 107, Page 9446-, Year 2010 |
| Publish date | Feb 3, 2010 (structure data deposition date) |
Authors | Murray, B. / Guo, C. / Piraino, J. / Westwick, J. / Zhang, C. / Lamerdin, J. / Dagostino, E. / Knighton, D.R. / Loi, C.-M. / Zager, M. ...Murray, B. / Guo, C. / Piraino, J. / Westwick, J. / Zhang, C. / Lamerdin, J. / Dagostino, E. / Knighton, D.R. / Loi, C.-M. / Zager, M. / Kraynov, E. / Popoff, I. / Christensen, J. / Martinez, R. / Kephart, S. / Marakovits, J. / Karlicek, S. / Bergqvist, S. / Smeal, T. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:20439741 |
| Methods | X-ray diffraction |
| Resolution | 2.1 Å |
| Structure data | ![]() PDB-2x4z: |
| Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-7KC: ![]() ChemComp-HOH: |
| Source |
|
Keywords | TRANSFERASE / NUCLEOTIDE-BINDING ATP-BINDING / PHOSPHOPROTEIN |
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homo sapiens (human)
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