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TitleIdentification of Novel Allosteric Inhibitors of Hepatitis C Virus Ns5B Polymerase Thumb Domain (Site II) by Structure-Based Design
Journal, issue, pagesTo be Published
Publish dateSep 1, 2009 (structure data deposition date)
AuthorsDi Francesco, M.E. / Di Marco, S. / Summa, V.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-2wrm:
Identification of Novel Allosteric Inhibitors of Hepatitis C Virus NS5B Polymerase Thumb Domain (Site II) by Structure-Based Design
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-QQ3:
(3R)-3-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLIN-2-YL)HEXANOIC ACID

ChemComp-HOH:
WATER

Source
  • hepatitis c virus
KeywordsTRANSFERASE / NON-NUCLEOSIDE INHIBITOR / NNI / VIRAL PROTEIN

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