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Structure paper

TitleStructural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Journal, issue, pagesStructure, Vol. 17, Page 1669-, Year 2009
Publish dateAug 6, 2009 (structure data deposition date)
AuthorsZogg, T. / Brandstetter, H.
External linksStructure / PubMed:20004170
MethodsX-ray diffraction
Resolution1.5 - 2.21 Å
Structure data

PDB-2wph:
factor IXa superactive triple mutant
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-2wpi:
factor IXa superactive double mutant
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-2wpj:
factor IXa superactive triple mutant, NaCl-soaked
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-2wpk:
factor IXa superactive triple mutant, ethylene glycol-soaked
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

PDB-2wpl:
factor IXa superactive triple mutant, EDTA-soaked
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-2wpm:
factor IXa superactive mutant, EGR-CMK inhibited
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsBLOOD CLOTTING / HYDROLASE / GLYCOPROTEIN / HEMOSTASIS / HEMOPHILIA / ZYMOGEN / HYDROXYLATION / PHOSPHOPROTEIN / XASE-LIKE VARIANT / GAMMA-CARBOXYGLUTAMIC ACID / SERINE PROTEASE / SULFATION / COMMUNICATION CHANNEL / EGF-LIKE DOMAIN / DISEASE MUTATION

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