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-Structure paper
Title | The Identification of Beta-Hydroxy Carboxylic Acids as Selective Mmp-12 Inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 5760-, Year 2009 |
Publish date | Jul 22, 2009 (structure data deposition date) |
![]() | Holmes, I.P. / Gaines, S. / Watson, S.P. / Lorthioir, O. / Walker, A. / Baddeley, S.J. / Herbert, S. / Egan, D. / Convery, M.A. / Singh, O.M.P. ...Holmes, I.P. / Gaines, S. / Watson, S.P. / Lorthioir, O. / Walker, A. / Baddeley, S.J. / Herbert, S. / Egan, D. / Convery, M.A. / Singh, O.M.P. / Gross, J.W. / Strelow, J.M. / Smith, R.H. / Amour, A.J. / Brown, D. / Martin, S.L. |
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Methods | X-ray diffraction |
Resolution | 1.7 - 2.3 Å |
Structure data | ![]() PDB-2wo8: ![]() PDB-2wo9: ![]() PDB-2woa: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-CA: ![]() ChemComp-077: ![]() ChemComp-SO4: ![]() ChemComp-023: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-068: ![]() ChemComp-576: |
Source |
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![]() | HYDROLASE / POLYMORPHISM / GLYCOPROTEIN / METAL-BINDING / MATRIX METALLOPROTEASE MMP-12 COMPLEX STRUCTURE / METALLOPROTEASE / EXTRACELLULAR MATRIX / ZYMOGEN / PROTEASE / SECRETED / DISULFIDE BOND / ZINC / CALCIUM |