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TitleIdentification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.
Journal, issue, pagesJ. Med. Chem., Vol. 52, Page 5217-5227, Year 2009
Publish dateMay 5, 2009 (structure data deposition date)
AuthorsOntoria, J.M. / Rydberg, E.H. / Di Marco, S. / Tomei, L. / Attenni, B. / Malancona, S. / Martin Hernando, J.I. / Gennari, N. / Koch, U. / Narjes, F. ...Ontoria, J.M. / Rydberg, E.H. / Di Marco, S. / Tomei, L. / Attenni, B. / Malancona, S. / Martin Hernando, J.I. / Gennari, N. / Koch, U. / Narjes, F. / Rowley, M. / Summa, V. / Carroll, S.S. / Olsen, D.B. / De Francesco, R. / Altamura, S. / Migliaccio, G. / Carfi, A.
External linksJ. Med. Chem. / PubMed:19877603
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2who:
CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-VGI:
2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione

ChemComp-HOH:
WATER

Source
  • hepatitis c virus
KeywordsTRANSFERASE / RNA REPLICATION / ENVELOPE PROTEIN / HEPATITIS C VIRUS / ENDOPLASMIC RETICULUM / NON NUCLEOSIDE INHIBITOR / VIRAL PROTEIN / METAL-BINDING / TRANSMEMBRANE / POLYMERASE / ATP-BINDING / GENOTYPE 1B / RNA-BINDING / RNA-DEPENDENT RNA POLYMERASE / NNI / HCV / NS5B / MEMBRANE / HELICASE / HYDROLASE / NUCLEOTIDE-BINDING / ALLOSTERIC INHIBITOR / RNA-DIRECTED RNA POLYMERASE

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