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-Structure paper
Title | Second Generation of Bace-1 Inhibitors Part 3: Towards Non Hydroxyethylamine Transition State Mimetics. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 3674-, Year 2009 |
Publish date | Apr 2, 2009 (structure data deposition date) |
Authors | Charrier, N. / Clarke, B. / Cutler, L. / Demont, E. / Dingwall, C. / Dunsdon, R. / Hawkins, J. / Howes, C. / Hubbard, J. / Hussain, I. ...Charrier, N. / Clarke, B. / Cutler, L. / Demont, E. / Dingwall, C. / Dunsdon, R. / Hawkins, J. / Howes, C. / Hubbard, J. / Hussain, I. / Maile, G. / Matico, R. / Mosley, J. / Naylor, A. / O'Brien, A. / Redshaw, S. / Rowland, P. / Soleil, V. / Smith, K.J. / Sweitzer, S. / Theobald, P. / Vesey, D. / Walter, D.S. / Wayne, G. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19406640 |
Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | PDB-2wf4: |
Chemicals | ChemComp-ZY4: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / MEMAPSIN-2 / POLYMORPHISM / GLYCOPROTEIN / ASP-2 / BACE-1 / ZYMOGEN / PROTEASE / MEMBRANE / TRANSMEMBRANE / BETA-SECRETASE / DISULFIDE BOND / ASPARTYL PROTEASE / ALTERNATIVE SPLICING / BETA-SITE APP CLEAVING ENZYME |