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Structure paper

TitleChimeric Microtubule Disruptors.
Journal, issue, pagesChem. Commun. (Camb. ), Vol. 46, Page 2907-, Year 2010
Publish dateMar 19, 2009 (structure data deposition date)
AuthorsLeese, M.P. / Jourdan, F.L. / Kimberley, M.R. / Cozier, G.E. / Thiyagarajan, N. / Stengel, C. / Regis-Lydi, S. / Foster, P.A. / Newman, S.P. / Acharya, K.R. ...Leese, M.P. / Jourdan, F.L. / Kimberley, M.R. / Cozier, G.E. / Thiyagarajan, N. / Stengel, C. / Regis-Lydi, S. / Foster, P.A. / Newman, S.P. / Acharya, K.R. / Ferrandis, E. / Purohit, A. / Reed, M.J. / Potter, B.V.L.
External linksChem. Commun. (Camb. ) / PubMed:20386818
MethodsX-ray diffraction
Resolution1.49 Å
Structure data

PDB-2wd2:
A chimeric microtubule disruptor with efficacy on a taxane resistant cell line
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MS5:
7-methoxy-2-(3-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-yl sulfamate

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE / DISEASE MUTATION / CANCER / HUMAN CARBONIC ANHYDRASE INHIBITORS / METAL-BINDING

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