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Structure paper

TitleThe X-Ray Structure of Ru486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation.
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 19572-, Year 2009
Publish dateJan 20, 2009 (structure data deposition date)
AuthorsRaaijmakers, H.C.A. / Versteegh, J. / Uitdehaag, J.C.M.
External linksJ. Biol. Chem. / PubMed:19372222
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-2w8y:
RU486 bound to the progesterone receptor in a destabilized agonistic conformation
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-486:
11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE

ChemComp-SO4:
SULFATE ION

ChemComp-NDR:
(14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one / medication, hormone*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsRECEPTOR / PROGESTERONE RECEPTOR / RU-486 / MIFEPRISTONE

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