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Title | Exploration of 4,4-Disubstituted Pyrrolidine-1,2-Dicarboxamides as Potent, Orally Active Factor Xa Inhibitors with Extended Duration of Action. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 17, Page 2501-, Year 2009 |
Publish date | Nov 12, 2008 (structure data deposition date) |
![]() | Van Huis, C.A. / Casimiro-Garcia, A. / Bigge, C.F. / Cody, W.L. / Dudley, D.A. / Filipski, K.J. / Heemstra, R.J. / Kohrt, J.T. / Leadley, R.J.J. / Narasimhan, L.S. ...Van Huis, C.A. / Casimiro-Garcia, A. / Bigge, C.F. / Cody, W.L. / Dudley, D.A. / Filipski, K.J. / Heemstra, R.J. / Kohrt, J.T. / Leadley, R.J.J. / Narasimhan, L.S. / Mcclanahan, T. / Mochalkin, I. / Pamment, M. / Peterson, J.T. / Sahasrabudhe, V. / Schaum, R.P. / Edmunds, J.J. |
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Methods | X-ray diffraction |
Resolution | 1.9 - 2.05 Å |
Structure data | ![]() PDB-2w3i: ![]() PDB-2w3k: |
Chemicals | ![]() ChemComp-CA: ![]() ChemComp-L1C: ![]() ChemComp-HOH: ![]() ChemComp-L1D: |
Source |
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![]() | HYDROLASE / DRUG DESIGN / GLYCOPROTEIN / HYDROXYLATION / BLOOD CLOTTING / SERINE PROTEASE / EGF-LIKE DOMAIN / FXA COAGULATION FACTOR INHIBITOR / ZYMOGEN / PROTEASE / SECRETED / BLOOD COAGULATION / GAMMA-CARBOXYGLUTAMIC ACID / CLEAVAGE ON PAIR OF BASIC RESIDUES |