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Structure paper

TitleStructure-Guided Inhibitor Design for Human Faah by Interspecies Active Site Conversion.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 105, Page 12820-, Year 2008
Publish dateJul 22, 2008 (structure data deposition date)
AuthorsMileni, M. / Johnson, D.S. / Wang, Z. / Everdeen, D.S. / Liimatta, M. / Pabst, B. / Bhattacharya, K. / Nugent, R.A. / Kamtekar, S. / Cravatt, B.F. ...Mileni, M. / Johnson, D.S. / Wang, Z. / Everdeen, D.S. / Liimatta, M. / Pabst, B. / Bhattacharya, K. / Nugent, R.A. / Kamtekar, S. / Cravatt, B.F. / Ahn, K. / Stevens, R.C.
External linksProc. Natl. Acad. Sci. USA / PubMed:18753625
MethodsX-ray diffraction
Resolution2.75 Å
Structure data

PDB-2vya:
Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-UNX:
Unknown entry

ChemComp-PF7:
4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsHYDROLASE / FATTY ACID AMIDE HYDROLYSE / GOLGI APPARATUS / ENDOPLASMIC RETICULUM / INHIBITOR / DRUG- LIKE / TRANSMEMBRANE / FAAH / CHIMERA / MEMBRANE / COVALENT / HUMANIZED

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