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Structure paper

TitleAcid Beta-Glucosidase: Insights from Structural Analysis and Relevance to Gaucher Disease Therapy.
Journal, issue, pagesBiol. Chem., Vol. 389, Page 1361-, Year 2008
Publish dateMay 3, 2008 (structure data deposition date)
AuthorsKacher, Y. / Brumshtein, B. / Boldin-Adamsky, S. / Toker, L. / Shainskaya, A. / Silman, I. / Sussman, J.L. / Futerman, A.H.
External linksBiol. Chem. / PubMed:18783340
MethodsX-ray diffraction
Resolution2.15 Å
Structure data

PDB-2vt0:
X-ray structure of a conjugate with conduritol-beta-epoxide of acid-beta-glucosidase overexpressed in cultured plant cells
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-CBU:
(1R,2R,3S,4S,5S,6S)-CYCLOHEXANE-1,2,3,4,5,6-HEXOL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / ALTERNATIVE INITIATION / SPHINGOLIPID METABOLISM / ISRAEL STRUCTURAL PROTEOMICS CENTER / DISEASE MUTATION / GLUCOCEREBROSIDASE / PHARMACEUTICAL / GAUCHER DISEASE / LIPID METABOLISM / GLUCOSIDASE / GLYCOSIDASE / POLYMORPHISM / GLYCOPROTEIN / ISPC / MEMBRANE / CEREZYME / LYSOSOME / STRUCTURAL GENOMICS / ALTERNATIVE SPLICING

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