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Structure paper

TitleA Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 15, Page 849-, Year 2008
Publish dateDec 6, 2007 (structure data deposition date)
AuthorsCordle, J. / Johnson, S. / Tay, J.Z. / Roversi, P. / Wilkin, M.B. / De Madrid, B.H. / Shimizu, H. / Jensen, S. / Whiteman, P. / Jin, B. ...Cordle, J. / Johnson, S. / Tay, J.Z. / Roversi, P. / Wilkin, M.B. / De Madrid, B.H. / Shimizu, H. / Jensen, S. / Whiteman, P. / Jin, B. / Redfield, C. / Baron, M. / Lea, S.M. / Handford, P.A.
External linksNat. Struct. Mol. Biol. / PubMed:18660822
MethodsX-ray diffraction
Resolution2.5 - 2.6 Å
Structure data

PDB-2vj2:
Human Jagged-1, domains DSL and EGFs1-3
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2vj3:
Human Notch-1 EGFs 11-13
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-MLT:
D-MALATE

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / SIGNALLING / POLYMORPHISM / GLYCOPROTEIN / EXTRACELLULAR / DEVELOPMENTAL PROTEIN / NOTCH SIGNALING PATHWAY / EGF / DSL / NOTCH / JAGGED / CALCIUM / MEMBRANE / PROTEIN-BINDING / TRANSMEMBRANE / EGF-LIKE DOMAIN / DISEASE MUTATION / TRANSCRIPTION / METAL-BINDING / DIFFERENTIATION / PHOSPHORYLATION / TRANSCRIPTION REGULATION / RECEPTOR / ACTIVATOR / ANK REPEAT / NUCLEUS

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