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-Structure paper
Title | 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. |
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Journal, issue, pages | J. Med. Chem., Vol. 51, Page 196-218, Year 2008 |
Publish date | Sep 24, 2007 (structure data deposition date) |
![]() | Brough, P.A. / Aherne, W. / Barril, X. / Borgognoni, J. / Boxall, K. / Cansfield, J.E. / Cheung, K.M. / Collins, I. / Davies, N.G. / Drysdale, M.J. ...Brough, P.A. / Aherne, W. / Barril, X. / Borgognoni, J. / Boxall, K. / Cansfield, J.E. / Cheung, K.M. / Collins, I. / Davies, N.G. / Drysdale, M.J. / Dymock, B. / Eccles, S.A. / Finch, H. / Fink, A. / Hayes, A. / Howes, R. / Hubbard, R.E. / James, K. / Jordan, A.M. / Lockie, A. / Martins, V. / Massey, A. / Matthews, T.P. / McDonald, E. / Northfield, C.J. / Pearl, L.H. / Prodromou, C. / Ray, S. / Raynaud, F.I. / Roughley, S.D. / Sharp, S.Y. / Surgenor, A. / Walmsley, D.L. / Webb, P. / Wood, M. / Workman, P. / Wright, L. |
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Methods | X-ray diffraction |
Resolution | 2 - 2.5 Å |
Structure data | ![]() PDB-2vci: ![]() PDB-2vcj: |
Chemicals | ![]() ChemComp-2GJ: ![]() ChemComp-HOH: ![]() ChemComp-2EQ: |
Source |
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![]() | CHAPERONE / ALTERNATIVE SPLICING / ATP-BINDING / PHOSPHORYLATION / CYTOPLASM / STRESS RESPONSE / NUCLEOTIDE-BINDING |