+Search query
-Structure paper
Title | Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 17, Page 2927-, Year 2007 |
Publish date | Mar 22, 2007 (structure data deposition date) |
Authors | Young, R.J. / Brown, D. / Burns-Kurtis, C.L. / Chan, C. / Convery, M.A. / Hubbard, J.A. / Kelly, H.A. / Pateman, A.J. / Patikis, A. / Senger, S. ...Young, R.J. / Brown, D. / Burns-Kurtis, C.L. / Chan, C. / Convery, M.A. / Hubbard, J.A. / Kelly, H.A. / Pateman, A.J. / Patikis, A. / Senger, S. / Shah, G.P. / Toomey, J.R. / Watson, N.S. / Zhou, P. |
External links | Bioorg. Med. Chem. Lett. / PubMed:17420122 |
Methods | X-ray diffraction |
Resolution | 1.75 - 1.9 Å |
Structure data | PDB-2uwl: PDB-2uwo: PDB-2uwp: |
Chemicals | ChemComp-895: ChemComp-HOH: ChemComp-701: ChemComp-894: ChemComp-CA: ChemComp-MG: |
Source |
|
Keywords | HYDROLASE / TARGET HOPPING / SERINE PROTEASE / EGF-LIKE DOMAIN / POLYMORPHISM / GLYCOPROTEIN / HYDROXYLATION / CALCIUM / ZYMOGEN / COMPLEX / PROTEASE / BLOOD COAGULATION / GAMMA- CARBOXYGLUTAMIC ACID / CLEAVAGE ON PAIR OF BASIC RESIDUES |