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TitleStructural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase.
Journal, issue, pagesNature, Vol. 448, Page 613-, Year 2007
Publish dateMar 2, 2007 (structure data deposition date)
AuthorsMartinez Molina, D. / Wetterholm, A. / Kohl, A. / Mccarthy, A.A. / Niegowski, D. / Ohlson, E. / Hammarberg, T. / Eshaghi, S. / Haeggstrom, J.Z. / Nordlund, P.
External linksNature / PubMed:17632546
MethodsX-ray diffraction
Resolution2 - 2.15 Å
Structure data

PDB-2uuh:
Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-2uui:
Crystal structure of Human Leukotriene C4 Synthase
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-LMU:
DODECYL-ALPHA-D-MALTOSIDE / detergent*YM

ChemComp-GSH:
GLUTATHIONE

ChemComp-PAM:
PALMITOLEIC ACID

ChemComp-PLM:
PALMITIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-LMT:
DODECYL-BETA-D-MALTOSIDE / detergent*YM

Source
  • homo sapiens (human)
KeywordsLYASE / MEMBRANE PROTEIN / LEUKOTRIENE SIGNALLING / MAPEG / HUMAN / LTC4S / ENZYME / TRIMER / MEMBRANE / LEUKOTRIENE BIOSYNTHESIS / EICOSANOID / GLUTATHIONE / TRANSMEMBRANE / APO

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