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TitleNovel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 1695-1705, Year 2008
Publish dateOct 18, 2007 (structure data deposition date)
AuthorsLa, D.S. / Belzile, J. / Bready, J.V. / Coxon, A. / Demelfi, T. / Doerr, N. / Estrada, J. / Flynn, J.C. / Flynn, S.R. / Graceffa, R.F. ...La, D.S. / Belzile, J. / Bready, J.V. / Coxon, A. / Demelfi, T. / Doerr, N. / Estrada, J. / Flynn, J.C. / Flynn, S.R. / Graceffa, R.F. / Harriman, S.P. / Larrow, J.F. / Long, A.M. / Martin, M.W. / Morrison, M.J. / Patel, V.F. / Roveto, P.M. / Wang, L. / Weiss, M.M. / Whittington, D.A. / Teffera, Y. / Zhao, Z. / Polverino, A.J. / Harmange, J.C.
External linksJ. Med. Chem. / PubMed:18311900
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-2rl5:
Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-2RL:
N-(4-CHLOROPHENYL)-7-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]-2,3-DIHYDRO-1,4-BENZOXAZINE-4-CARBOXAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / receptor tyrosine kinase / angiogenesis / ATP-binding / Developmental protein / Differentiation / Glycoprotein / Host-virus interaction / Immunoglobulin domain / Membrane / Nucleotide-binding / Phosphorylation / Polymorphism / Transmembrane / Tyrosine-protein kinase

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