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TitleSynthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 2292-2295, Year 2008
Publish dateSep 5, 2007 (structure data deposition date)
AuthorsLee, J. / Choi, H. / Kim, K.H. / Jeong, S. / Park, J.W. / Baek, C.S. / Lee, S.H.
External linksBioorg. Med. Chem. Lett. / PubMed:18353638
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-2r64:
Crystal structure of a 3-aminoindazole compound with CDK2
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-740:
N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / protein kinase / inhibitor / cell division / ATP-binding / Cell cycle / Mitosis / Nucleotide-binding / Phosphorylation / Polymorphism / Serine/threonine-protein kinase

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