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Structure paper

TitleStructure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Journal, issue, pagesChem. Biol., Vol. 15, Page 920-929, Year 2008
Publish dateSep 3, 2007 (structure data deposition date)
AuthorsTholander, F. / Muroya, A. / Roques, B.P. / Fournie-Zaluski, M.C. / Thunnissen, M.M. / Haeggstrom, J.Z.
External linksChem. Biol. / PubMed:18804029
MethodsX-ray diffraction
Resolution1.465 - 2.3 Å
Structure data

PDB-2r59:
Leukotriene A4 hydrolase complexed with inhibitor RB3041
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

PDB-3b7r:
Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040
Method: X-RAY DIFFRACTION / Resolution: 1.811 Å

PDB-3b7s:
[E296Q]LTA4H in complex with RSR substrate
Method: X-RAY DIFFRACTION / Resolution: 1.465 Å

PDB-3b7t:
[E296Q]LTA4H in complex with Arg-Ala-Arg substrate
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-3b7u:
Leukotriene A4 Hydrolase Complexed with KELatorphan
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-YB:
YTTERBIUM (III) ION

ChemComp-PH0:
N-{(2S)-3-[(R)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine

ChemComp-ACY:
ACETIC ACID

ChemComp-HOH:
WATER

ChemComp-IMD:
IMIDAZOLE

ChemComp-BIR:
N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE

ChemComp-GOL:
GLYCEROL

ChemComp-KEL:
N-[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]-L-alanine / inhibitor*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / transition state / analogue peptide / hydrolysis / Alternative splicing / Cytoplasm / Leukotriene biosynthesis / Metal-binding / Metalloprotease / Multifunctional enzyme / Protease / Zinc / TRIPEPTIDE SUBSTRATE

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