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Structure paper

TitleStructures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Journal, issue, pagesBiochem. J., Vol. 408, Page 193-201, Year 2007
Publish dateAug 15, 2007 (structure data deposition date)
AuthorsWang, H. / Peng, M.S. / Chen, Y. / Geng, J. / Robinson, H. / Houslay, M.D. / Cai, J. / Ke, H.
External linksBiochem. J. / PubMed:17727341
MethodsX-ray diffraction
Resolution1.57 - 2.1 Å
Structure data

PDB-2qyk:
Crystal structure of PDE4A10 in complex with inhibitor NPV
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2qyl:
Crystal structure of PDE4B2B in complex with inhibitor NPV
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-2qym:
crystal structure of unliganded PDE4C2
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-2qyn:
Crystal structure of PDE4D2 in complex with inhibitor NPV
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

Chemicals

ChemComp-NPV:
4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PDE4 inhibitor / subfamily inhibitor selectivity / PDE4B structure / selective inhibitor NVP / PDE4C structure / PDE4D selective inhibitor NVP / Alternative splicing / cAMP / Cytoplasm / Cytoskeleton / Membrane / Metal-binding / Phosphorylation

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