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-Structure paper
Title | Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates |
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Journal, issue, pages | Bioorg. Chem., Vol. 36, Page 85-90, Year 2008 |
Publish date | Aug 10, 2007 (structure data deposition date) |
Authors | Sachdeva, S. / Musayev, F. / Alhamadsheh, M.M. / Neel Scarsdale, J. / Tonie Wright, H. / Reynolds, K.A. |
External links | Bioorg. Chem. / PubMed:18096200 |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-2qx1: |
Chemicals | ChemComp-COA: ChemComp-D1T: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / FATTY ACID BIOSYNTHESIS / MYOBACTERIUM TUBERCULOSIS / STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY / ENZYME INHIBITOR COMPLEX / MECHANISM BASED INHIBITOR / Acyltransferase / Lipid synthesis / Multifunctional enzyme |