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TitleDiscovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 418-422, Year 2008
Publish dateJul 16, 2007 (structure data deposition date)
AuthorsIserloh, U. / Pan, J. / Stamford, A.W. / Kennedy, M.E. / Zhang, Q. / Zhang, L. / Parker, E.M. / McHugh, N.A. / Favreau, L. / Strickland, C. / Voigt, J.
External linksBioorg. Med. Chem. Lett. / PubMed:17980584
MethodsX-ray diffraction
Resolution1.89 Å
Structure data

PDB-2qmg:
Structure of BACE Bound to SCH745966
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

Chemicals

ChemComp-SC6:
N-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-2-[(2R,4R)-4-PHENOXYPYRROLIDIN-2-YL]ETHYL}-3-{[(2R)-2-(METHOXYMETHYL)PYRROLIDIN-1-YL]CARBONYL}-5-METHYLBENZAMIDE

ChemComp-TAR:
D(-)-TARTARIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / BACE1 / protease / Alternative splicing / Aspartyl protease / Glycoprotein / Membrane / Transmembrane / Zymogen

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