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TitleCrystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 104, Page 13942-13947, Year 2007
Publish dateJul 11, 2007 (structure data deposition date)
AuthorsParthier, C. / Kleinschmidt, M. / Neumann, P. / Rudolph, R. / Manhart, S. / Schlenzig, D. / Fanghanel, J. / Rahfeld, J.-U. / Demuth, H.-U. / Stubbs, M.T.
External linksProc. Natl. Acad. Sci. Usa / PubMed:17715056
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-2qkh:
Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-TAR:
D(-)-TARTARIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/HORMONE / GPCR / incretin / hormone-GPCR complex / extracellular domain / ligand binding domain / ECD / glugacon receptor family / hormone recognition fold / diabetes / helix formation / Cleavage on pair of basic residues / Polymorphism / Alternative splicing / G-protein coupled receptor / Glycoprotein / Membrane / Transducer / Transmembrane / SIGNALING PROTEIN-HORMONE COMPLEX

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