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Title | (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 17, Page 5638-5642, Year 2007 |
Publish date | Jul 9, 2007 (structure data deposition date) |
![]() | Wright, S.W. / Ammirati, M.J. / Andrews, K.M. / Brodeur, A.M. / Danley, D.E. / Doran, S.D. / Lillquist, J.S. / Liu, S. / McClure, L.D. / McPherson, R.K. ...Wright, S.W. / Ammirati, M.J. / Andrews, K.M. / Brodeur, A.M. / Danley, D.E. / Doran, S.D. / Lillquist, J.S. / Liu, S. / McClure, L.D. / McPherson, R.K. / Olson, T.V. / Orena, S.J. / Parker, J.C. / Rocke, B.N. / Soeller, W.C. / Soglia, C.B. / Treadway, J.L. / Vanvolkenburg, M.A. / Zhao, Z. / Cox, E.D. |
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Methods | X-ray diffraction |
Resolution | 2.2 Å |
Structure data | ![]() PDB-2qjr: |
Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-PZF: ![]() ChemComp-LGU: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / protein-inhibitor complex / Aminopeptidase / Glycoprotein / Membrane / Protease / Secreted / Serine protease / Signal-anchor / Transmembrane |