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Structure paper

TitleSynthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 5019-5024, Year 2007
Publish dateJun 20, 2007 (structure data deposition date)
AuthorsMurali Dhar, T.G. / Wrobleski, S.T. / Lin, S. / Furch, J.A. / Nirschl, D.S. / Fan, Y. / Todderud, G. / Pitt, S. / Doweyko, A.M. / Sack, J.S. ...Murali Dhar, T.G. / Wrobleski, S.T. / Lin, S. / Furch, J.A. / Nirschl, D.S. / Fan, Y. / Todderud, G. / Pitt, S. / Doweyko, A.M. / Sack, J.S. / Mathur, A. / McKinnon, M. / Barrish, J.C. / Dodd, J.H. / Schieven, G.L. / Leftheris, K.
External linksBioorg. Med. Chem. Lett. / PubMed:17664068
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-2qd9:
P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-LGF:
1-[5-[[3-[2,4-bis(fluoranyl)phenyl]-6,8-dihydro-5~{H}-imidazo[1,5-a]pyrazin-7-yl]carbonyl]-6-methoxy-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-2-[(3~{R})-3-oxidanylpyrrolidin-1-yl]ethane-1,2-dione

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / KINASE / P38 MAP KINASE

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