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Structure paper

TitleDistinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol.
Journal, issue, pagesStructure, Vol. 15, Page 992-1004, Year 2007
Publish dateJun 10, 2007 (structure data deposition date)
AuthorsKato, M. / Li, J. / Chuang, J.L. / Chuang, D.T.
External linksStructure / PubMed:17683942
MethodsX-ray diffraction
Resolution1.9 - 2.6 Å
Structure data

PDB-2q8f:
Structure of pyruvate dehydrogenase kinase isoform 1
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-2q8g:
Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-2q8h:
Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (DCA)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2q8i:
Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-AZX:
4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE

ChemComp-TF4:
DICHLORO-ACETIC ACID

ChemComp-RDC:
RADICICOL

ChemComp-GOL:
GLYCEROL

ChemComp-RED:
DIHYDROLIPOIC ACID

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / GHKL ATPase/kinase family / pyruvate dehydrogenase complex / mitochondrial kinase / glucose-lowering drug AZD7545 / dichroloacetate / radicicol

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