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TitleDesign and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 4531-4537, Year 2007
Publish dateJun 4, 2007 (structure data deposition date)
AuthorsPfefferkorn, J.A. / Choi, C. / Song, Y. / Trivedi, B.K. / Larsen, S.D. / Askew, V. / Dillon, L. / Hanselman, J.C. / Lin, Z. / Lu, G. ...Pfefferkorn, J.A. / Choi, C. / Song, Y. / Trivedi, B.K. / Larsen, S.D. / Askew, V. / Dillon, L. / Hanselman, J.C. / Lin, Z. / Lu, G. / Robertson, A. / Sekerke, C. / Auerbach, B. / Pavlovsky, A. / Harris, M.S. / Bainbridge, G. / Caspers, N.
External linksBioorg. Med. Chem. Lett. / PubMed:17574411
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2q6b:
Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2q6c:
Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HR2:
(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID

ChemComp-HOH:
WATER

ChemComp-HR1:
(3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / CHOLESTEROL BIOSYNTHESIS / HMG-COA / NADPH / STATIN

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