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Structure paper

TitleTargeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis
Journal, issue, pagesChem. Biol., Vol. 15, Page 1296-1306, Year 2008
Publish dateNov 29, 2006 (structure data deposition date)
AuthorsArtz, J.D. / Dunford, J.E. / Arrowood, M.J. / Dong, A. / Chruszcz, M. / Kavanagh, K.L. / Minor, W. / Russell, R.G. / Ebetino, F.H. / Oppermann, U. / Hui, R.
External linksChem. Biol. / PubMed:19101474
MethodsX-ray diffraction
Resolution2.37 - 2.42 Å
Structure data

PDB-2o1o:
Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with risedronate.
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

PDB-2q58:
Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with zoledronate
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-RIS:
1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID

ChemComp-HOH:
WATER

ChemComp-ZOL:
ZOLEDRONIC ACID / medication*YM

Source
  • cryptosporidium parvum (eukaryote)
KeywordsSTRUCTURAL GENOMICS / UNKNOWN FUNCTION / putative polyprenyl pyrophosphate synthase / Structural Genomics Consortium / SGC / TRANSFERASE / FARNESYL DIPHOSPHATE SYNTHASE

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