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Structure paper

TitleCrystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 22185-22194, Year 2007
Publish dateMar 18, 2007 (structure data deposition date)
AuthorsWu, J. / Tao, Y. / Zhang, M. / Howard, M.H. / Gutteridge, S. / Ding, J.
External linksJ. Biol. Chem. / PubMed:17513302
MethodsX-ray diffraction
Resolution2.9 - 3.1 Å
Structure data

PDB-2p6e:
Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-2p6f:
Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-2p6g:
Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-MYA:
TETRADECANOYL-COA

ChemComp-GN8:
(Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE

ChemComp-3LP:
1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSFERASE / N-myristoyltransferase / substrate recognition / antifungal drug / non-peptidic inhibitor

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