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TitleSubstituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPAR Agonists. 1.Discovery of a Novel Series of Potent HDLc Raising Agents.
Journal, issue, pagesJ. Med. Chem., Vol. 50, Page 685-695, Year 2007
Publish dateMar 14, 2007 (structure data deposition date)
AuthorsSierra, M.L. / Beneton, V. / Boullay, A.B. / Boyer, T. / Brewster, A. / Donche, F. / Forest, M.C. / Fouchet, M.H. / Gellibert, F.J. / Grillot, D.A. ...Sierra, M.L. / Beneton, V. / Boullay, A.B. / Boyer, T. / Brewster, A. / Donche, F. / Forest, M.C. / Fouchet, M.H. / Gellibert, F.J. / Grillot, D.A. / Lambert, M.H. / Laroze, A. / Grumelec, C.L. / Linget, J.M. / Montana, V.G. / Nguyen, V.L. / Nicodeme, E. / Patel, V. / Penfornis, A. / Pineau, O. / Pohin, D. / Potvain, F. / Paulain, G. / Ruault, C.B. / Saunders, M. / Toum, J. / Xu, H.E. / Xu, R.X. / Pianetti, P.M.
External linksJ. Med. Chem. / PubMed:17243659
MethodsX-ray diffraction
Resolution1.79 Å
Structure data

PDB-2p54:
a crystal structure of PPAR alpha bound with SRC1 peptide and GW735
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

Chemicals

ChemComp-735:
2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / PPAR alpha GW735 SRC1 agonist HDLc

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