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-Structure paper
Title | Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. |
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Journal, issue, pages | Nat. Struct. Mol. Biol., Vol. 14, Page 413-419, Year 2007 |
Publish date | Mar 12, 2007 (structure data deposition date) |
Authors | Cunningham, D. / Danley, D.E. / Geoghegan, K.F. / Griffor, M.C. / Hawkins, J.L. / Subashi, T.A. / Varghese, A.H. / Ammirati, M.J. / Culp, J.S. / Hoth, L.R. ...Cunningham, D. / Danley, D.E. / Geoghegan, K.F. / Griffor, M.C. / Hawkins, J.L. / Subashi, T.A. / Varghese, A.H. / Ammirati, M.J. / Culp, J.S. / Hoth, L.R. / Mansour, M.N. / McGrath, K.M. / Seddon, A.P. / Shenolikar, S. / Stutzman-Engwall, K.J. / Warren, L.C. / Xia, D. / Qiu, X. |
External links | Nat. Struct. Mol. Biol. / PubMed:17435765 |
Methods | X-ray diffraction |
Resolution | 1.98 Å |
Structure data | PDB-2p4e: |
Chemicals | ChemComp-HG: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / protease / subtilisin / LDL receptor / LDL / endocytosis |