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Structure paper

TitleStructural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
Journal, issue, pagesJ. Mol. Biol., Vol. 372, Page 723-736, Year 2007
Publish dateMar 9, 2007 (structure data deposition date)
AuthorsEgloff, M.P. / Decroly, E. / Malet, H. / Selisko, B. / Benarroch, D. / Ferron, F. / Canard, B.
External linksJ. Mol. Biol. / PubMed:17686489
MethodsX-ray diffraction
Resolution1.801 - 2.756 Å
Structure data

PDB-2p3l:
Crystal Structure of Dengue Methyltransferase in Complex with GpppA and S-Adenosyl-L-Homocysteine
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2p3o:
Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppA and S-Adenosyl-L-homocysteine
Method: X-RAY DIFFRACTION / Resolution: 2.756 Å

PDB-2p3q:
Crystal Structure of Dengue Methyltransferase in Complex with GpppG and S-Adenosyl-L-homocysteine
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-2p40:
Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG
Method: X-RAY DIFFRACTION / Resolution: 2.701 Å

PDB-2p41:
Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG2'OMe and S-Adenosyl-L-homocysteine
Method: X-RAY DIFFRACTION / Resolution: 1.801 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-G3A:
GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE

ChemComp-CIT:
CITRIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-GTA:
P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE

ChemComp-GP3:
DIGUANOSINE-5'-TRIPHOSPHATE

ChemComp-GTG:
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE

ChemComp-G1G:
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-(2'-O-METHYL)-GUANOSINE

Source
  • dengue virus 2
KeywordsVIRAL PROTEIN / TRANSFERASE / VIZIER; Viral Enzymes Involved in Replication; Dengue virus methyltransferase; Structural Genomics; Marseilles Structural Genomics Program @ AFMB; MSGP

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