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TitleA tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Journal, issue, pagesJ. Med. Chem., Vol. 50, Page 2408-2414, Year 2007
Publish dateMar 7, 2007 (structure data deposition date)
AuthorsVogensen, S.B. / Frydenvang, K. / Greenwood, J.R. / Postorino, G. / Nielsen, B. / Pickering, D.S. / Ebert, B. / Bolcho, U. / Egebjerg, J. / Gajhede, M. ...Vogensen, S.B. / Frydenvang, K. / Greenwood, J.R. / Postorino, G. / Nielsen, B. / Pickering, D.S. / Ebert, B. / Bolcho, U. / Egebjerg, J. / Gajhede, M. / Kastrup, J.S. / Johansen, T.N. / Clausen, R.P. / Krogsgaard-Larsen, P.
External linksJ. Med. Chem. / PubMed:17455929
MethodsX-ray diffraction
Resolution2.26 Å
Structure data

PDB-2p2a:
X-ray structure of the GluR2 ligand binding core (S1S2J) in complex with 2-Bn-tet-AMPA at 2.26A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-MP9:
2-AMINO-3-[3-HYDROXY-5-(2-BENZYL-2H-5-TETRAZOLYL)-4-ISOXAZOLYL]-PROPIONIC ACID

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / ionotropic glutamate receptor GluR2 / ligand-binding core / agonist complex

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