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TitleSynthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 2622-2628, Year 2007
Publish dateJan 19, 2007 (structure data deposition date)
AuthorsAhn, J.H. / Shin, M.S. / Jun, M.A. / Jung, S.H. / Kang, S.K. / Kim, K.R. / Rhee, S.D. / Kang, N.S. / Kim, S.Y. / Sohn, S.K. ...Ahn, J.H. / Shin, M.S. / Jun, M.A. / Jung, S.H. / Kang, S.K. / Kim, K.R. / Rhee, S.D. / Kang, N.S. / Kim, S.Y. / Sohn, S.K. / Kim, S.G. / Jin, M.S. / Lee, J.O. / Cheon, H.G. / Kim, S.S.
External linksBioorg. Med. Chem. Lett. / PubMed:17331715
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-2ole:
Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Cyclic Hydrazine Derivatives
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-KR2:
(2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / dipeptidyl peptidase iv / cyclic hydrazine / diabetes

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